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KMID : 0613820230330030252
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Journal of Life Science
2023 Volume.33 No. 3 p.252 ~ p.259
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Effect of Gastrodia elata Blume Extract (TVB-1000) on the Menopausal Disorder Model in Ovariectomized Rats
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Lim Hae-Ryeong
Ji Eun-Su
Byun Hak-Kyu
Lee So-Min
Ryu Hyeon-Yeol
Lee Deug-Chan
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Abstract
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A decrease in ovarian function and sex hormone production with aging results in hormone deficiency, which causes menopause in women. Natural products have been investigated to develop estrogen-like substances to improve menopausal status in women. This study was performed to evaluate the efficacy of Gastrodia elata Blume extract (TVB-1000) in ovariectomized rats. After a recovery period of 7 days, the TVB-1000 treatment group was orally administered at 16, 40, and 100 mg/kg for 12 weeks. In the OVX-positive control group, 17β-estradiol was injected subcutaneously into the dorsal region of rats at a dose of 10 μg/kg. Results show that TG and LDL-C, which are cardiovascular disease markers, were significantly decreased in all concentrations of TVB-1000 administration in the treatment group, and the LDL-C/HDL-C ratio significantly decreased in the medium and high TVB-1000 concentrations of the treatment group. In addition, in the high concentration TVB-1000 treatment group, the weight of abdominal fat decreased with statistical significance. The low-dose and medium-dose administration groups showed statistical significance and the expression level of their ER-α increased, but ER-β did not show a significant change. The above experiment shows that owing to the estrogen-like effect of TVB-1000, it can be useful as a functional food material to prevent cardiovascular disease, which is one of the menopausal symptoms.
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KEYWORD
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Gastrodia elata Blume, menopausal, ovariectomized rats
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